Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.
Dr. Greg Maguire’s thought-provoking book offers a radically new approach to the standard means of developing drugs through the use of the molecules that stem cells release. Emphasizing that living organisms operate through the collective actions of entities within and between all levels of the biological organism, including the quantum level, molecular level, and cellular level, for example, the argument is put forth that drug development, and medicine itself, must treat various indications by understanding and then treating the collective actions at the relevant levels that are found to be perturbed in that particular indication. Motivated by the recent successes in the fields of quantum collective electrodynamics and condensed matter physics, where systems level thinking has explained through mathematical and conceptual reasoning how these phenomenon work, and doing so with heuristic outcomes, Maguire argues that the same system level thinking must be applied to drug development and medicine. The interactive nature of these fundamental collective processes is at the core of developing “systems therapeutics” and, as such, challenges those that believe in fundamental reductionism, where understanding the components of the system will explain the system. During these times, fundamental reductionism is often used to explain diseases as the result of an aberration in a DNA sequence, and targeted approaches to drug development lead to the development of small molecules to specifically target only one pathway. The last chapter culminates in showing how the “systems therapeutic” approach using the molecules from adult stem cells is used to treat neurodegeneration. (Nova Biomedical)
A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.
- Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy
- Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials
- Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward
- Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies