This book is a comprehensive guide on neural stem cell behavior in health and disease. It will cover the altered behavior of endogenous neural stem cells in neurodegenerative conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders.First set of chapters will focus on neural stem cell proliferation, neuronal differentiation and maturation of progeny of cells derived from neural stem cells in brain regions, such as the hippocampus and the subventricular zone of the forebrain. Neural stem cell behavior in young and aged brains and functional implications of altered neural stem cell behavior will be discussed as well.The second set of chapters will cover altered behavior of endogenous neural stem cells and their functional implications in disorders, such as temporal lobe epilepsy, cancer, traumatic brain injury, stroke, Alzheimer’s disease, addiction and alcohol use.The third set of chapters will discuss prospects of stem cell therapy for various neurological disorders, which will comprise of their behavior after grafting and functional recovery mediated by them. Additional chapters will discuss how to generate the right neural cell types from induced pluripotent stem cells for screening and cell therapy of central nervous system disorders.
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson’s, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and ‘bench to bedside’. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
Promising treatments now in more than 35,000 clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. These treatments, which are saving the lives of patients in the trials, will soon be rolled to the medical community at large.
The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Research has found that our bodies are virtual treasure troves of adult cells that act as agents of remarkable healing and repair. These cells have been called adult stem cells because they resemble embryonic cells in their ability to transform into many other cell types but without the ethical and moral concerns of embryonic cells.
Adult cells can reprogram cells to work more efficiently. They can also carry edited genetic code to repair mistakes, and deliver targeted therapies, allowing them to address and even cure many diseases affecting children and adults.
The applications of these cellular therapies are broad and growing. Regenerative medicine allows doctors to repair injured and aging tissues and, incredibly, to create artificial body parts and organs in the lab.