This study covers the world outlook for human embryonic stem cell (hESC) research across more than 190 countries. For each year reported, estimates are given for the latent demand, or potential industry earnings (P.I.E.), for the country in question (in millions of U.S. dollars), the percent share the country is of the region, and of the globe. These comparative benchmarks allow the reader to quickly gauge a country vis-à-vis others. Using econometric models which project fundamental economic dynamics within each country and across countries, latent demand estimates are created. This report does not discuss the specific players in the market serving the latent demand, nor specific details at the product level. The study also does not consider short-term cyclicalities that might affect realized sales. The study, therefore, is strategic in nature, taking an aggregate and long-run view, irrespective of the players or products involved. This study does not report actual sales data (which are simply unavailable, in a comparable or consistent manner in virtually all of the countries of the world). This study gives, however, my estimates for the worldwide latent demand, or the P.I.E., for human embryonic stem cell (hESC) research. It also shows how the P.I.E. is divided across the world’s regional and national markets. For each country, I also show my estimates of how the P.I.E. grows over time (positive or negative growth). In order to make these estimates, a multi-stage methodology was employed that is often taught in courses on international strategic planning at graduate schools of business.
With this valuable practical guide, three members of the HarvardStem Cell Institute have compiled and edited the definite handbookfor the exciting new field of human embryonic stem cell research.The editors have gathered protocols from scientists with extensivereputation and expertise, describing and comparing currently usedtechniques for the culture of human stem cells and discussing thestrengths and weaknesses of the different approaches.
Human Embryonic Stem Cells: The PracticalHandbook contains the first centralised collection ofmethods used in human embryonic stem cell biology. The book coversthe derivation of human stem cell lines, the obtaining of cellsfrom human stem cell banks, the culturing and characterisation ofthe cells, and the differentiation of the cells in vitro andin vivo. Lastly, almost all of these protocols can also beused for analyzing and manipulating induced pluripotency iPS stemcells. This allows an even greater number of opportunities forthose interested in purusing work in pluripotent stem cells,disease modelling, and other aspects of basic regenerative medicineresearch.
The novel and useful focus of this book sets it apart from otheravailable books:
- Compares and evaluates the protocols used in leadinglaboratories working on human embryonic stem cells
- Centred solely on practical protocols for human (not mouse)embryonic stem cell research
- Includes extensive troubleshooting sections
- Addresses the different proclivities and behaviours ofindividual human embryonic cell lines
- Contains techniques currently known only to a small number ofspecialised laboratories worldwide
This handbook represents an essential source of up-to-datepractical information for all cell and developmental biologistsworking with human embryonic stem cells or wishing to enter thefield. It is also essential reading for clinical researchersin areas such as diabetes, cardiovascular disease, and neurologicaldiseases.
Praise from the reviews:
“…a highly readable and useful book… A notablefeature of the book is its air of openness and honesty… Thisbook… will help many to navigate the uncharted waters ofhuman embryonic stem cell biology.” BRITISH SOCIETY FOR CELLBIOLOGY
“… the imaginative solutions in this book can inspire us toget past our most frustrating limitations.” CELL STEM CELL
“… the richness in the details of each protocol presentedwill certainly encourage more scientists to begin studies of Humanpluripotent stem cells…” REGENERATIVE MEDICINE
“In this fast-moving field, this [handbook] will help driveadvances of more and more researchers.” DIFFERENTIATION
“…a valuable resource for seasoned and noviceresearchers… an excellent addition to the reference collection ofany medical library or research laboratory.” THE AMERICANMEDICAL ASSOCIATION
In 2005, the National Academies released the book, Guidelines for Human Embryonic Stem Cell Research, which offered a common set of ethical standards for a field that, due to the absence of comprehensive federal funding, was lacking national standards for research. In order to keep the Guidelines up to date, given the rapid pace of scientific and policy developments in the field of stem cell research, the Human Embryonic Stem Cell Research Advisory Committee was established in 2006 with support from The Ellison Medical Foundation, The Greenwall Foundation, and the Howard Hughes Medical Institute.
As it did in 2007 and 2008, the Committee identified issues that warranted revision, and this book addresses those issues in a third and final set of amendments. Specifically, this book sets out an updated version of the National Academies’ Guidelines, one that takes into account the new, expanded role of the NIH in overseeing hES cell research. It also identifies those avenues of continuing National Academies’ involvement deemed most valuable by the research community and other significant stakeholders.