Handbook of Theories of Aging, Third Edition

This state-of-the-art handbook will keep researchers and practitioners in gerontology abreast of the newest theories and models of aging. With virtually all new contributors and content, this edition contains 35 chapters by the most highly respected luminaries in the field. It addresses theories and concepts built on cumulative knowledge in four disciplinary areasóbiology, psychology, social sciences, and policy and practiceóas well as landmark advances in trans-disciplinary science. With its explicit focus on theory, the handbook is unique in providing essential knowledge about primary explanations for aging, spanning from cells to societies.

The chapters in the third edition place a strong emphasis on the future of theory development, assessing the current state of theories and providing a roadmap for how theory can shape research, and vice versa, in years to come. Many chapters also address connections between theories and policy or practice. Each set of authors has been asked to consider how theories in their area address matters of diversity and inequalities in aging, and how theories might be revised or tested with these matters in mind. The third edition also contains a new section, “Standing on the Shoulders of Giants,” which includes personal essays by senior gerontologists who share their perspectives on the history of ideas in their fields, and on their experiences with the process and prospects of developing good theory.

Hallmarks of the Third Edition:

  • Highlights important gains in trans-disciplinary theories of aging

  • Emphasizes the future of theory development

  • Provides insights on theory development from living legends in gerontology

  • Examines what human diversity and inequality mean for aging theories

  • Emphasizes interconnections between theory, research, intervention, and policy

  • Underscores international issues with greater representation of international authors

  • Includes section introductions by the editors and associate editors that summarize theoretical developments

Key Features:

  • Highlights variability and diversity in aging processes, from the cellular level of biological aging to the societal level of public policy

  • Provides insights on theory development from living legends in gerontology

  • Offers intergenerational, interdisciplinary, and international perspectives

  • Disseminates a forward-thinking, future-oriented focus in theory development

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Hematopoietic Stem Cell Transplantation: A Handbook for Clinicians, 2nd edition

This second edition of Hematopoietic Stem Cell Transplantation: A Handbook for Clinicians (HSCT) offers comprehensive and practical information for healthcare providers working in the HSCT field. It provides relevant information on all areas of HSCT, including indications for transplantation; donor and patient evaluation; conditioning regimens; collection, processing, and characterization of stem cell products; management of immunosuppressive therapy; evaluation and management of the most common complications during HSCT; supportive care management; common procedures; and aspects of follow-up care. The emphasis of the Handbook is placed on providing up-to-date information in a clinically meaningful way.
This edition s content has been reorganized to facilitate finding topics of interest more easily and the authors emphasized an educational bent in presenting their material. Each of the topics in the first edition has been revised to ensure the content is up to date. New chapters covering nonmalignant diseases, haploidentical transplants, photopheresis, financial considerations, and iron overload have been added.

Topics include:
General Principles
Pretransplant Concerns
Donor Selection
Graft Preparation
Infusion and Support
Outcomes
Complications

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Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition

The Most Comprehensive, State-of-the-Art Book on Using Gene and Cell Therapy in Clinical Medicine

Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. The fourth edition of this bestseller continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors’ research efforts as well as current technologies, disease targets, and clinical applications.

Divided into four sections, the book covers:

  • Delivery systems and therapeutic strategies
  • Other therapeutic strategies, including technologies that knock down gene expression
  • Gene expression, regulation, and detection
  • Gene and cell therapies, disease targets, clinical trials, and regulatory issues

Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to state-of-the-art technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.

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