This book provides a concise and contemporary account of the state of stem cell research in the fields of toxicology and teratology. It contains background information on the features of stem cells that render them highly focused and practical research tools for toxicology and teratology. Also presented are summaries of the production of cardiomyocytes, hepatocytes, and neurons from pluripotent cells (the cell types involved in the majority of toxicological responses), and their use to detect potentially hazardous xenobiotic compounds. Though most of this book considers the use of pluripotent stem cells, the authors also include chapters that discuss unusually effective immortalized cell lines that can be coaxed to differentiate (rather like stem cells) into specialized cells resembling relevant adult cell types, which is particularly useful for toxicology science.
Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.