Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.
This may be the only available account of not one but two stem cell transplants told by the patient and his wife caretaker written as journals while the events were unfolding. Barry was diagnosed with Chronic Lymphocytic Leukemia in 2005 and died in 2014. Bonnie, his wife of 37 years, became his caregiver. This book, their real time journals, vividly depicts their rollercoaster ride from diagnosis to hope to despair to hope, up and down, over and over again. Bonnie and Barry recount the harrowing experience of the two stem cell transplants in wildly different but equally compelling accounts of apparently the same events. Readers will be breathless as they turn the page to learn what happened next. Ultimately, this is a story about how love survives death.
Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.
- Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
- Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
- Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types