This may be the only available account of not one but two stem cell transplants told by the patient and his wife caretaker written as journals while the events were unfolding. Barry was diagnosed with Chronic Lymphocytic Leukemia in 2005 and died in 2014. Bonnie, his wife of 37 years, became his caregiver. This book, their real time journals, vividly depicts their rollercoaster ride from diagnosis to hope to despair to hope, up and down, over and over again. Bonnie and Barry recount the harrowing experience of the two stem cell transplants in wildly different but equally compelling accounts of apparently the same events. Readers will be breathless as they turn the page to learn what happened next. Ultimately, this is a story about how love survives death.
Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.
- Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
- Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
- Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types
How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation.
This book discusses some of the recent advances in stem cell research that may help understanding the properties of the niche that govern stem cell fate. Technical topics discussed include:
- Stem cell biology
- Cancer stem cells
- Stem cell interactions with biomaterials
- Engineering the stem cell microenvironment
- Stem cells in tissue regeneration and repair
The Disputationes Workshop series is an international initiative aimed at disseminating stem cell related cutting edge knowledge among scientists, healthcare workers, students and policy makers. This book emerges as a result of the scientific contributions presented and discussed during the fifth Disputationes Workshop held in Aalborg (Denmark) in April 2014. The stem cell microenvironment and its role in regenerative medicine and cancer pathogenesis is ideal for academic staff and master/research students in biomedical and health sciences