This reference presents insights into the development of bone marrow aspirate stem cell (BMAC) technology and the potential role of stem cell expansion in the regeneration of damaged and deficient musculoskeletal tissues. The book features valuable contributions from stem cell therapy experts from around the world. The authors explain the production, proliferation, differentiation into various tissues, and medical applications of stem cells. In addition to work on the use of stem cells in the treatment of non-unions and bone defects, the book explores the potential for articular cartilage regeneration, repair of tendon injuries, the treatment of degenerative joint disease, revascularization of bone and regeneration of damaged nerves as well as spinal cord injury. The authors also explain ethical challenges faced by researchers and public authorities working on stem cells and the varying constraints on the development of this technology around the world. Scientists and surgeons, alike, who are involved in the fields of orthopaedics, rheumatology, stem cell and regenerative medicine will benefit from the illuminating snapshot of the applications of BMAC stem cell expansion presented in the volume.
This is the first experimental protocol book that covers the differentiation of bone marrow-derived stem cells (BMSCs) into specific cell types, targeted at the undergraduate and graduate student level. The 19 chapters deal with the differentiation methods using small molecules, cytokines and polymeric scaffolds.
BMSCs are pluripotential in that they not only act as myelo-regenerative and supportive cells, but can also differentiate into almost any kind of cells in our body. In addition, when implanted in vivo, they could help repair multiple tissues such as blood vessels, heart, liver and so on.
For the differentiation of BMSCs, many methods have been introduced to adjust their microenvironment (chemical and physical cues), including chemical induction methods using large or small molecules and pellet culture; mechanical stimulation induction methods using cyclic mechano-transduction or ultrasonication; cytokine-released method using scaffolds; and so on.
Readership: Undergraduate and graduate students and researchers in biomedical engineering, tissue engineering, stem cell research, nanotechnology and material science.
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