This invaluable resource discusses the current revolution in stem cell-based drugs and their potential use in clinical applications. Each chapter is contributed by a pre-eminent scientist in the field. An introductory section presents current stem cell drugs and stem cell-based products and a discussion of production, quality control, mechanisms, and efficacy. Following sections include discussions on stem cell-derived microvesicles based products, and derived exosomes based products.
A comprehensive reference and teaching aid on tissue engineering—covering everything from the basics of regenerative medicine to more advanced and forward thinking topics such as the artificial liver, bladder, and trachea
Regenerative medicine/tissue engineering is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. It is an incredibly progressive field of medicine that may, in the near future, help with the shortage of life-saving organs available through donation for transplantation.
Introduction to Tissue Engineering: Applications and Challenges makes tissue engineering more accessible to undergraduate and graduate students alike. It provides a systematic and logical eight-step process for tissue fabrication. Specific chapters have been dedicated to provide in-depth principles for many of the supporting and enabling technologies during the tissue fabrication process and include biomaterial development and synthesis, bioreactor design, and tissue vascularization. The tissue fabrication process is further illustrated with specific examples for liver, bladder, and trachea. Section-coverage includes an overall introduction of tissue engineering; enabling and supporting technologies; clinical applications; and case studies and future challenges.
Introduction to Tissue Engineering:
- Presents medical applications of stem cells in tissue engineering
- Deals with the effects of chemical stimulation (growth factors and hormones)
- Covers current disease pathologies and treatment options (pacemakers, prosthesis)
- Explains bioengineering, design and fabrication, and critical challenges during tissue fabrication
- Offers PowerPoint slides for instructors
- Features case studies and a section on future directions and challenges
As pioneering individuals look ahead to the possibility of generating entire organ systems, students may turn to this text for a comprehensive understanding and preparation for the future of regenerative medicine.
Cutting-edge coverage of stem cell biology and applications
Featuring contributions from leading global experts, this authoritative volume addresses all major areas of stem cell biology and their potential therapeutic applications. The first part of the book covers embryonic stem cells and contains details on the emerging field of embryonic stem cell-based drug screening platforms. The second part deals with multipotent adult stem cells from different tissue types, and covers unique concepts such as cancer stem cells and tissue engineering-based approaches for designing microenvironments for tissue regeneration. Eighty pages of inserts with 113 color figures are included in this pioneering work.
- Zebrafish, medaka, chicken embryonic, and mouse embryonic stem cells
- Derivation of human embryonic stem cells (hESCs) from blastocysts
- Treating diabetes with hESCs
- hESCs as a model system to study human genetics
- Application of hESCs in drug discovery
- Adult stem cells for regenerative medicine and cancer therapies
- Mesenchymal stem cells for neurodegenerative disease therapies
- Dental pulp, hematopoietic, and spermatogonial stem cells
- Epigenetic regulators of stem cell pluripotency
- Cancer stem cells