Originally published in 1994, this readable and well-structured text opens with an overview of the concepts behind and advantages of blood stem cell transplants. Detailed concepts of their use are later expanded upon and critically reviewed by experts. Among the important issues discussed are hematopoietic recovery, tumor contamination and techniques used to purify stem cells. Clinical trial data follow including leukemia, lymphoma, myeloma and breast cancer. The final chapter evaluates progress in the use of blood stem cells and points possible clinical directions. This is a detailed review of the techniques in blood stem cell transplants which will be of value to anyone with an interest in the area.
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases.
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson’s, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and ‘bench to bedside’. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge.
Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver
Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more
Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation