Autophagy in Health and Disease: Potential Therapeutic Approaches (Stem Cell Biology and Regenerative Medicine)

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. 

The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson’s, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and ‘bench to bedside’. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.

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Stem Cells and Cancer in Hepatology: From the Essentials to Application

Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge.

  • Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver
  • Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more
  • Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation

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Handbook of Theories of Aging, Third Edition

This state-of-the-art handbook will keep researchers and practitioners in gerontology abreast of the newest theories and models of aging. With virtually all new contributors and content, this edition contains 35 chapters by the most highly respected luminaries in the field. It addresses theories and concepts built on cumulative knowledge in four disciplinary areasóbiology, psychology, social sciences, and policy and practiceóas well as landmark advances in trans-disciplinary science. With its explicit focus on theory, the handbook is unique in providing essential knowledge about primary explanations for aging, spanning from cells to societies.

The chapters in the third edition place a strong emphasis on the future of theory development, assessing the current state of theories and providing a roadmap for how theory can shape research, and vice versa, in years to come. Many chapters also address connections between theories and policy or practice. Each set of authors has been asked to consider how theories in their area address matters of diversity and inequalities in aging, and how theories might be revised or tested with these matters in mind. The third edition also contains a new section, “Standing on the Shoulders of Giants,” which includes personal essays by senior gerontologists who share their perspectives on the history of ideas in their fields, and on their experiences with the process and prospects of developing good theory.

Hallmarks of the Third Edition:

  • Highlights important gains in trans-disciplinary theories of aging

  • Emphasizes the future of theory development

  • Provides insights on theory development from living legends in gerontology

  • Examines what human diversity and inequality mean for aging theories

  • Emphasizes interconnections between theory, research, intervention, and policy

  • Underscores international issues with greater representation of international authors

  • Includes section introductions by the editors and associate editors that summarize theoretical developments

Key Features:

  • Highlights variability and diversity in aging processes, from the cellular level of biological aging to the societal level of public policy

  • Provides insights on theory development from living legends in gerontology

  • Offers intergenerational, interdisciplinary, and international perspectives

  • Disseminates a forward-thinking, future-oriented focus in theory development

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