Cell-Based Therapy for Degenerative Retinal Disease (Stem Cell Biology and Regenerative Medicine)

This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.

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The Lung: Developmental Morphogenesis, Mechanobiology, and Stem Cells (Regenerative Medicine, Artificial Cells and Nanomedicine)

With detailed scientific background and up-to-date research, this book examines recent developmental and cell biology, mechanobiology and stem cell biology discoveries to help provide a better understanding of lung development, repair and regeneration. Lung regeneration is an urgent therapeutic priority. The current major challenge is the generation of complex vascularized structures that can ultimately support or replace impaired lung function. Recent discoveries in biomedical engineering are analysed within the structural context of the lung to help provide a better understanding of the innovative solutions that could be used for restoring normal morphogenesis and regeneration of the lung. This also includes insights from basic developmental mechanisms of human lung development through the derivation and identification of stem cells, both from the early embryo as well as from differentiated organs and tissues. Suitable for a wide range of readers, including physicians and surgeons, scientists and researchers, and undergraduate and postgraduate students, this guide is an essential read for those working in the field of lung disease and development.

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Establishing a Hematopoietic Stem Cell Transplantation Unit: A Practical Guide

This text aims to provide simplified practical guidelines to start a hematopoietic stem cell transplantation unit which could be implemented in most centers and countries worldwide. The book also provides guidelines for existing transplantation units to upgrade their practice and implement new policies and procedures, in addition to developing therapies according to latest international standards and regulations.
The book covers a wide range of practical implementation tools including HSCT program team structure, building inpatient and outpatient HSCT units, requisite laboratory support for transplantation program, practical aspects of stem cell collection and processing, HSCT program quality management, education and training, and data management. The book also addresses cost effectiveness and recommendations for establishing transplantation program in countries with limited resources. 
Written by group of internationally established experts in their corresponding hematopoietic stem cell transplantation fields, with contributions from many leaders of hematopoietic stem cell transplantation organizations, Establishing a Hematopoietic Stem Cell Transplantation Unit: A Practical Guide is an essential, practical resource for all members of the multidisciplinary hematopoietic stem cell transplantation team.

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