SCF, or c-kit ligand or steel factor, is a hematopoietic growth factor that exerts its activity by signaling through CD117, the c-Kit receptor. Soluble and transmembrane SCF is produced by a variety of cells including fibroblasts and endothelial cells and is critical for driving HSC survival, proliferation and differentiation. SCF potentially effects stem cell niche or microenvironment of stem cell location affecting HSC maintenance and along with SDF-1, allows stem cells to relocate into the niche. SCF plays a role in hematopoiesis, spermatogenesis, melanocyte development and other developmental activities. In vitro SCF and c-Kit also increase megakaryocyte development. SCF has clinical value for bone marrow transplantation but also enhances allergic reactions due to mast cell expansion through the CD117 c-kit receptor. Name: Recombinant Mouse Stem Cell Factor (SCF) (Carrier-free) Cat. No.: 21-8341 Alternative Names: c-kit ligand, steel factor Amino Acid Sequence: MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA Authenticity: Verified by N-terminal and Mass Spectrometry analyses (when applicable). Bioactivity: ED50 is 1 x 105 units/mg calculated by stimulation of the proliferation of the human TF-1 cells. Endotoxin Level: Endotoxin level is <0.1 ng/Î¼g of protein (<1 EU/Î¼g). Molecular Mass: Recombinant Mouse SCF is an 18.3 kDa polypeptide containing 164 amino acid residues, identical to the sequence of secreted soluble form of SCF. Protein Content: Content Verified by UV Spectroscopy and/or SDS-PAGE gel. Purity (%): 98 Source: E. coli Reactivity: Mouse Research Areas: Cell Culture, Proliferation, Stem Cells and Differentiation Reconstitution: See Certificate of Analysis (COA) for lot specific reconstitution information.
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