This book presents a comprehensive overview of the current understanding of the organization of endogenous lung stem and progenitor cell compartments during fetal lung development, postnatal lung growth and in adulthood. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine. The scope of this volume of the Stem Cell Biology and Regenerative Medicine series focuses on exploring the topic of building and rebuilding the lung from a cellular rather than a molecular perspective. Thus, the section on cellular therapies does not include extensive coverage of each of the numerous lung diseases, including cancer, which could be amenable to stem cell-based therapies, although the final chapter does include some discussion on the future prospects and challenges. All of the contributors are working on the cutting edge of the lung stem cell field, making this book essential reading for those with an interest in the field of lung stem cell biology and the potential role of cellular therapies and tissue bioengineering approaches in lung regenerative medicine, including biomedical scientists, graduate students, post-graduate researchers and respiratory clinicians.
This book provides comprehensive insights into the field of stem cell biology. Stem cells refer to the undifferentiated biological cells that can divide themselves through mitosis to form more stem cells. These cells are generally seen in multicellular organisms and are of two types, namely, embryonic stem cells and adult stem cells. They are found in embryos, fetuses and some adult tissues. This book unravels the recent studies in the field of stem cells. It will also provide interesting topics for research which readers can take up. From theories to research to practical applications, case studies from across the globe related to stem cell biology, have been included in this book. Students, scientists, biologists, doctors and other interested readers will benefit alike from this text.
The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues.
• Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications
• Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models
• Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues
• Written and edited by leaders in the field
The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.
About the Author
Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.